Insider Trading disclosures for Prothena Corporation plc

The latest disclosure was made by Tran B. Nguyen in Prothena Corporation plc where a trade of 107,500 Stock Option (Right to Buy) done was reported to US exchanges on March 5, 2025.

Insider trading is the trading of a company’s securities by individuals with access to confidential or material non-public information about the company. A company is required to report trading by corporate officers, directors, or other company members with significant access to privileged information to the Securities and Exchange Commission (SEC).

Client Name	Client Category	Action	Reported to Exchange	Quantity	Post Transaction Holding	Traded %	Avg. Price	Value	Security Type
Tran B. Nguyen	Chief Strategy Officer and CFO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	05 Mar 2025	107,500	107,500	-		-	Stock Option (Right to Buy)
Carol D. Karp	Chief Regulatory Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	05 Mar 2025	107,500	107,500	-		-	Stock Option (Right to Buy)
Karin L. Walker	Chief Accounting Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	05 Mar 2025	70,000	70,000	-		-	Stock Option (Right to Buy)
Gene G. Kinney	Director, President and CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	05 Mar 2025	375,000	375,000	-		-	Stock Option (Right to Buy)
David A. Ford	Chief People Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	05 Mar 2025	107,500	107,500	-		-	Stock Option (Right to Buy)
Wagner M. Zago	Chief Scientific Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	05 Mar 2025	107,500	107,500	-		-	Stock Option (Right to Buy)
Michael J. Malecek	Chief Legal Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	05 Mar 2025	107,500	107,500	-		-	Stock Option (Right to Buy)
Brandon S. Smith	Chief Operating Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	05 Mar 2025	107,500	107,500	-		-	Stock Option (Right to Buy)
Chad J. Swanson	Chief Development Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	05 Mar 2025	107,500	107,500	-		-	Stock Option (Right to Buy)
Chad J. Swanson	Chief Development Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Oct 2024	40,000	40,000	-		-	Stock Option (Right to Buy)
Daniel G. Welch	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 May 2024	15,000	15,000	-		-	Stock Option (Right to Buy)
Helen S. Kim	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 May 2024	15,000	15,000	-		-	Stock Option (Right to Buy)
Richard T. Collier	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 May 2024	15,000	15,000	-		-	Stock Option (Right to Buy)
Dennis J. Selkoe	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 May 2024	15,000	15,000	-		-	Stock Option (Right to Buy)
Lars G. Ekman	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 May 2024	15,000	15,000	-		-	Stock Option (Right to Buy)
Shane M. Cooke	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 May 2024	15,000	15,000	-		-	Stock Option (Right to Buy)
Paula K. Cobb	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 May 2024	15,000	15,000	-		-	Stock Option (Right to Buy)
William H. Dunn	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 May 2024	15,000	15,000	-		-	Stock Option (Right to Buy)
Garren Hideki	Chief Medical Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	27 Feb 2024	85,000	85,000	-		-	Stock Option (Right to Buy)
Kinney Gene G.	President and CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	27 Feb 2024	307,000	307,000	-		-	Stock Option (Right to Buy)
Wagner M. Zago	Chief Scientific Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	27 Feb 2024	85,000	85,000	-		-	Stock Option (Right to Buy)
D. Karp Carol	Chief Regulatory Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	27 Feb 2024	85,000	85,000	-		-	Stock Option (Right to Buy)
Nguyen B. Tran	Chief Strategy Officer and CFO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	27 Feb 2024	85,000	85,000	-		-	Stock Option (Right to Buy)
Smith Brandon S.	Chief Operating Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	27 Feb 2024	85,000	85,000	-		-	Stock Option (Right to Buy)
Michael Malecek J.	Chief Legal Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	27 Feb 2024	85,000	85,000	-		-	Stock Option (Right to Buy)
L. Walker Karin	Chief Accounting Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	27 Feb 2024	54,000	54,000	-		-	Stock Option (Right to Buy)
G. Daniel Welch	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Feb 2024	132,000	132,000	-		-	Stock Option (Right to Buy)
Walker L. Karin	Chief Accounting Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	24 Jan 2024	5,000	15,000	-		-	Stock Option (Right to Buy)
Karin Walker L.	Chief Accounting Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.53 per share.	24 Jan 2024	5,000	5,000 (0%)	0%	13.5	67,650	Ordinary Shares, par value $0.01 per share
Karin L. Walker	Chief Accounting Officer	Sale of securities on an exchange or to another person at price $ 34.00 per share.	24 Jan 2024	5,000	0 (0%)	0%	34	170,000	Ordinary Shares, par value $0.01 per share
Walker L. Karin	Chief Accounting Officer	Sale of securities on an exchange or to another person at price $ 37.45 per share.	20 Dec 2023	3,322	0 (0%)	0%	37.5	124,409	Ordinary Shares, par value $0.01 per share
L. Karin Walker	Chief Accounting Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	20 Dec 2023	5,000	20,000	-		-	Stock Option (Right to Buy)
Walker L. Karin	Chief Accounting Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.53 per share.	20 Dec 2023	5,000	5,000 (0%)	0%	13.5	67,650	Ordinary Shares, par value $0.01 per share
Walker Karin L.	Chief Accounting Officer	Sale of securities on an exchange or to another person at price $ 36.68 per share.	20 Dec 2023	1,678	3,322 (0%)	0%	36.7	61,543	Ordinary Shares, par value $0.01 per share
Michael J. Malecek	Chief Legal Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	30 Aug 2023	5,000	95,000	-		-	Stock Option (Right to Buy)
Michael J. Malecek	Chief Legal Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.27 per share.	30 Aug 2023	5,000	5,000 (0%)	0%	10.3	51,350	Ordinary Shares, par value $0.01 per share
Michael J. Malecek	Chief Legal Officer	Sale of securities on an exchange or to another person at price $ 54.58 per share.	30 Aug 2023	2,322	2,678 (0%)	0%	54.6	126,728	Ordinary Shares, par value $0.01 per share
Michael J. Malecek	Chief Legal Officer	Sale of securities on an exchange or to another person at price $ 55.39 per share.	30 Aug 2023	2,664	14 (0%)	0%	55.4	147,551	Ordinary Shares, par value $0.01 per share
Michael J. Malecek	Chief Legal Officer	Sale of securities on an exchange or to another person at price $ 56.21 per share.	30 Aug 2023	14	0 (0%)	0%	56.2	787	Ordinary Shares, par value $0.01 per share
Brandon S. Smith	Chief Operating Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	16 Aug 2023	4,000	226,667	-		-	Stock Option (Right to Buy)
Brandon S. Smith	Chief Operating Officer	Sale of securities on an exchange or to another person at price $ 59.15 per share.	16 Aug 2023	1,373	401 (0%)	0%	59.2	81,217	Ordinary Shares, par value $0.01 per share
Brandon S. Smith	Chief Operating Officer	Sale of securities on an exchange or to another person at price $ 58.22 per share.	16 Aug 2023	2,226	1,774 (0%)	0%	58.2	129,602	Ordinary Shares, par value $0.01 per share
Brandon S. Smith	Chief Operating Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 11.12 per share.	16 Aug 2023	4,000	4,000 (0%)	0%	11.1	44,480	Ordinary Shares, par value $0.01 per share
Brandon S. Smith	Chief Operating Officer	Sale of securities on an exchange or to another person at price $ 59.91 per share.	16 Aug 2023	401	0 (0%)	0%	59.9	24,025	Ordinary Shares, par value $0.01 per share
Hideki Garren	Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 24.90 per share.	16 Aug 2023	2,000	2,000 (0%)	0%	24.9	49,800	Ordinary Shares, par value $0.01 per share
Hideki Garren	Chief Medical Officer	Sale of securities on an exchange or to another person at price $ 58.15 per share.	16 Aug 2023	878	1,122 (0%)	0%	58.2	51,059	Ordinary Shares, par value $0.01 per share
Hideki Garren	Chief Medical Officer	Sale of securities on an exchange or to another person at price $ 58.93 per share.	16 Aug 2023	748	374 (0%)	0%	58.9	44,079	Ordinary Shares, par value $0.01 per share
Hideki Garren	Chief Medical Officer	Sale of securities on an exchange or to another person at price $ 59.74 per share.	16 Aug 2023	374	0 (0%)	0%	59.7	22,341	Ordinary Shares, par value $0.01 per share
Hideki Garren	Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	16 Aug 2023	2,000	194,000	-		-	Stock Option (Right to Buy)
Carol Karp	Chief Regulatory Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.15 per share.	02 Aug 2023	5,000	5,000 (0%)	0%	12.2	60,750	Ordinary Shares, par value $0.01 per share
Carol Karp	Chief Regulatory Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	02 Aug 2023	5,000	55,000	-		-	Stock Option (Right to Buy)
Carol Karp	Chief Regulatory Officer	Sale of securities on an exchange or to another person at price $ 67.95 per share.	02 Aug 2023	328	0 (0%)	0%	68.0	22,288	Ordinary Shares, par value $0.01 per share
Carol Karp	Chief Regulatory Officer	Sale of securities on an exchange or to another person at price $ 66.95 per share.	02 Aug 2023	4,672	328 (0%)	0%	66.9	312,784	Ordinary Shares, par value $0.01 per share
Wagner M. Zago	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	02 Aug 2023	4,000	58,000	-		-	Stock Option (Right to Buy)
Wagner M. Zago	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 68.07 per share.	02 Aug 2023	229	0 (0%)	0%	68.1	15,589	Ordinary Shares, par value $0.01 per share
Wagner M. Zago	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 66.98 per share.	02 Aug 2023	3,771	229 (0%)	0%	67.0	252,593	Ordinary Shares, par value $0.01 per share
Wagner M. Zago	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.15 per share.	02 Aug 2023	4,000	4,000 (0%)	0%	12.2	48,600	Ordinary Shares, par value $0.01 per share
Michael J. Malecek	Chief Legal Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	26 Jul 2023	5,000	100,000	-		-	Stock Option (Right to Buy)
Michael J. Malecek	Chief Legal Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.27 per share.	26 Jul 2023	5,000	5,000 (0%)	0%	10.3	51,350	Ordinary Shares, par value $0.01 per share
Michael J. Malecek	Chief Legal Officer	Sale of securities on an exchange or to another person at price $ 61.78 per share.	26 Jul 2023	2,477	2,523 (0%)	0%	61.8	153,032	Ordinary Shares, par value $0.01 per share
Michael J. Malecek	Chief Legal Officer	Sale of securities on an exchange or to another person at price $ 62.69 per share.	26 Jul 2023	1,903	620 (0%)	0%	62.7	119,297	Ordinary Shares, par value $0.01 per share
Michael J. Malecek	Chief Legal Officer	Sale of securities on an exchange or to another person at price $ 63.40 per share.	26 Jul 2023	620	0 (0%)	0%	63.4	39,309	Ordinary Shares, par value $0.01 per share
Karin L. Walker	Chief Accounting Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	19 Jul 2023	5,000	10,481	-		-	Stock Option (right to buy)
Karin L. Walker	Chief Accounting Officer	Sale of securities on an exchange or to another person at price $ 70.08 per share.	19 Jul 2023	1,034	0 (0%)	0%	70.1	72,459	Ordinary Shares, par value $0.01 per share
Karin L. Walker	Chief Accounting Officer	Sale of securities on an exchange or to another person at price $ 68.96 per share.	19 Jul 2023	3,966	1,034 (0%)	0%	69.0	273,484	Ordinary Shares, par value $0.01 per share
Karin L. Walker	Chief Accounting Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.04 per share.	19 Jul 2023	5,000	5,000 (0%)	0%	15.0	75,200	Ordinary Shares, par value $0.01 per share
Brandon S. Smith	Chief Operating Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	12 Jul 2023	4,000	230,667	-		-	Stock Option (Right to Buy)
Brandon S. Smith	Chief Operating Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 11.12 per share.	12 Jul 2023	4,000	4,000 (0%)	0%	11.1	44,480	Ordinary Shares, par value $0.01 per share
Brandon S. Smith	Chief Operating Officer	Sale of securities on an exchange or to another person at price $ 67.40 per share.	12 Jul 2023	3,200	800 (0%)	0%	67.4	215,667	Ordinary Shares, par value $0.01 per share
Brandon S. Smith	Chief Operating Officer	Sale of securities on an exchange or to another person at price $ 67.95 per share.	12 Jul 2023	800	0 (0%)	0%	67.9	54,358	Ordinary Shares, par value $0.01 per share
Hideki Garren	Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 24.90 per share.	12 Jul 2023	2,000	2,000 (0%)	0%	24.9	49,800	Ordinary Shares, par value $0.01 per share
Hideki Garren	Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	12 Jul 2023	2,000	196,000	-		-	Stock Option (Right to Buy)
Hideki Garren	Chief Medical Officer	Sale of securities on an exchange or to another person at price $ 68.20 per share.	12 Jul 2023	92	0 (0%)	0%	68.2	6,274	Ordinary Shares, par value $0.01 per share
Hideki Garren	Chief Medical Officer	Sale of securities on an exchange or to another person at price $ 67.48 per share.	12 Jul 2023	1,908	92 (0%)	0%	67.5	128,753	Ordinary Shares, par value $0.01 per share
Carol Karp	Chief Regulatory Officer	Sale of securities on an exchange or to another person at price $ 68.69 per share.	05 Jul 2023	1,034	0 (0%)	0%	68.7	71,027	Ordinary Shares, par value $0.01 per share
Carol Karp	Chief Regulatory Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.15 per share.	05 Jul 2023	5,000	5,000 (0%)	0%	12.2	60,750	Ordinary Shares, par value $0.01 per share
Carol Karp	Chief Regulatory Officer	Sale of securities on an exchange or to another person at price $ 67.98 per share.	05 Jul 2023	3,966	1,034 (0%)	0%	68.0	269,609	Ordinary Shares, par value $0.01 per share
Carol Karp	Chief Regulatory Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	05 Jul 2023	5,000	60,000	-		-	Stock Option (Right to Buy)
Wagner M. Zago	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 68.69 per share.	05 Jul 2023	1,009	0 (0%)	0%	68.7	69,306	Ordinary Shares, par value $0.01 per share
Wagner M. Zago	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 67.98 per share.	05 Jul 2023	2,991	1,009 (0%)	0%	68.0	203,342	Ordinary Shares, par value $0.01 per share
Wagner M. Zago	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.15 per share.	05 Jul 2023	4,000	4,000 (0%)	0%	12.2	48,600	Ordinary Shares, par value $0.01 per share
Wagner M. Zago	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	05 Jul 2023	4,000	62,000	-		-	Stock Option (Right to Buy)
Dennis J Selkoe	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 11.33 per share.	03 Jul 2023	5,000	7,845 (0%)	0%	11.3	56,650	Ordinary Shares, par value $0.01 per share
Dennis J Selkoe	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Jul 2023	5,000	12,500	-		-	Stock Option (Right to Buy)
Dennis J Selkoe	Director	Sale of securities on an exchange or to another person at price $ 67.43 per share.	03 Jul 2023	5,000	2,845 (0%)	0%	67.4	337,150	Ordinary Shares, par value $0.01 per share
Michael J. Malecek	Chief Legal Officer	Sale of securities on an exchange or to another person at price $ 69.07 per share.	28 Jun 2023	1,240	3,760 (0%)	0%	69.1	85,644	Ordinary Shares, par value $0.01 per share
Michael J. Malecek	Chief Legal Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.27 per share.	28 Jun 2023	5,000	5,000 (0%)	0%	10.3	51,350	Ordinary Shares, par value $0.01 per share
Michael J. Malecek	Chief Legal Officer	Sale of securities on an exchange or to another person at price $ 70.84 per share.	28 Jun 2023	710	0 (0%)	0%	70.8	50,295	Ordinary Shares, par value $0.01 per share
Michael J. Malecek	Chief Legal Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	28 Jun 2023	5,000	105,000	-		-	Stock Option (Right to Buy)
Michael J. Malecek	Chief Legal Officer	Sale of securities on an exchange or to another person at price $ 69.89 per share.	28 Jun 2023	3,050	710 (0%)	0%	69.9	213,178	Ordinary Shares, par value $0.01 per share
Karin L. Walker	Chief Accounting Officer	Sale of securities on an exchange or to another person at price $ 69.49 per share.	20 Jun 2023	2,471	529 (0%)	0%	69.5	171,699	Ordinary Shares, par value $0.01 per share
Karin L. Walker	Chief Accounting Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	20 Jun 2023	5,000	15,481	-		-	Stock Option (right to buy)
Karin L. Walker	Chief Accounting Officer	Sale of securities on an exchange or to another person at price $ 69.99 per share.	20 Jun 2023	529	0 (0%)	0%	70.0	37,027	Ordinary Shares, par value $0.01 per share
Karin L. Walker	Chief Accounting Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.04 per share.	20 Jun 2023	5,000	5,000 (0%)	0%	15.0	75,200	Ordinary Shares, par value $0.01 per share
Karin L. Walker	Chief Accounting Officer	Sale of securities on an exchange or to another person at price $ 67.88 per share.	20 Jun 2023	2,000	3,000 (0%)	0%	67.9	135,768	Ordinary Shares, par value $0.01 per share
Carol Karp	Chief Regulatory Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.15 per share.	07 Jun 2023	5,000	5,000 (0%)	0%	12.2	60,750	Ordinary Shares, par value $0.01 per share
Carol Karp	Chief Regulatory Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.53 per share.	07 Jun 2023	15,000	20,000 (0%)	0%	13.5	202,950	Ordinary Shares, par value $0.01 per share
Carol Karp	Chief Regulatory Officer	Sale of securities on an exchange or to another person at price $ 69.90 per share.	07 Jun 2023	3,046	16,954 (0%)	0%	69.9	212,916	Ordinary Shares, par value $0.01 per share
Carol Karp	Chief Regulatory Officer	Sale of securities on an exchange or to another person at price $ 71.00 per share.	07 Jun 2023	12,782	4,172 (0%)	0%	71.0	907,495	Ordinary Shares, par value $0.01 per share
Carol Karp	Chief Regulatory Officer	Sale of securities on an exchange or to another person at price $ 71.97 per share.	07 Jun 2023	3,811	361 (0%)	0%	72.0	274,271	Ordinary Shares, par value $0.01 per share
Carol Karp	Chief Regulatory Officer	Sale of securities on an exchange or to another person at price $ 72.93 per share.	07 Jun 2023	361	0 (0%)	0%	72.9	26,328	Ordinary Shares, par value $0.01 per share
Carol Karp	Chief Regulatory Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	07 Jun 2023	5,000	65,000	-		-	Stock Option (Right to Buy)
Carol Karp	Chief Regulatory Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	07 Jun 2023	15,000	35,000	-		-	Stock Option (Right to Buy)
Wagner M. Zago	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	07 Jun 2023	15,000	0	-		-	Stock Option (Right to Buy)
Wagner M. Zago	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	07 Jun 2023	4,000	66,000	-		-	Stock Option (Right to Buy)
Wagner M. Zago	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 73.14 per share.	07 Jun 2023	294	0 (0%)	0%	73.1	21,503	Ordinary Shares, par value $0.01 per share
Wagner M. Zago	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 71.96 per share.	07 Jun 2023	3,759	294 (0%)	0%	72.0	270,479	Ordinary Shares, par value $0.01 per share
Wagner M. Zago	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 70.99 per share.	07 Jun 2023	12,004	4,053 (0%)	0%	71.0	852,181	Ordinary Shares, par value $0.01 per share
Wagner M. Zago	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 70.02 per share.	07 Jun 2023	2,943	16,057 (0%)	0%	70.0	206,061	Ordinary Shares, par value $0.01 per share
Wagner M. Zago	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.15 per share.	07 Jun 2023	4,000	19,000 (0%)	0%	12.2	48,600	Ordinary Shares, par value $0.01 per share
Wagner M. Zago	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 29.81 per share.	07 Jun 2023	15,000	15,000 (0%)	0%	29.8	447,150	Ordinary Shares, par value $0.01 per share
Michael J. Malecek	Chief Legal Officer	Sale of securities on an exchange or to another person at price $ 64.16 per share.	31 May 2023	3,211	1,789 (0%)	0%	64.2	206,025	Ordinary Shares, par value $0.01 per share
Michael J. Malecek	Chief Legal Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	31 May 2023	5,000	110,000	-		-	Stock Option (Right to Buy)
Michael J. Malecek	Chief Legal Officer	Sale of securities on an exchange or to another person at price $ 65.98 per share.	31 May 2023	711	0 (0%)	0%	66.0	46,913	Ordinary Shares, par value $0.01 per share
Michael J. Malecek	Chief Legal Officer	Sale of securities on an exchange or to another person at price $ 65.20 per share.	31 May 2023	1,078	711 (0%)	0%	65.2	70,286	Ordinary Shares, par value $0.01 per share
Michael J. Malecek	Chief Legal Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.27 per share.	31 May 2023	5,000	5,000 (0%)	0%	10.3	51,350	Ordinary Shares, par value $0.01 per share
Karin L. Walker	Chief Accounting Officer	Sale of securities on an exchange or to another person at price $ 73.63 per share.	19 May 2023	2,823	2,177 (0%)	0%	73.6	207,850	Ordinary Shares, par value $0.01 per share
Karin L. Walker	Chief Accounting Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.04 per share.	19 May 2023	5,000	5,000 (0%)	0%	15.0	75,200	Ordinary Shares, par value $0.01 per share
Karin L. Walker	Chief Accounting Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	19 May 2023	5,000	20,481	-		-	Stock Option (right to buy)
Karin L. Walker	Chief Accounting Officer	Sale of securities on an exchange or to another person at price $ 74.47 per share.	19 May 2023	2,177	0 (0%)	0%	74.5	162,128	Ordinary Shares, par value $0.01 per share
Tran B. Nguyen	Chief Strategy Officer and CFO	Sale of securities on an exchange or to another person at price $ 75.44 per share.	17 May 2023	9,215	3,300 (0%)	0%	75.4	695,206	Ordinary Shares, par value $0.01 per share
Tran B. Nguyen	Chief Strategy Officer and CFO	Sale of securities on an exchange or to another person at price $ 74.55 per share.	17 May 2023	37,044	12,515 (0%)	0%	74.5	2,761,475	Ordinary Shares, par value $0.01 per share
Tran B. Nguyen	Chief Strategy Officer and CFO	Sale of securities on an exchange or to another person at price $ 73.54 per share.	17 May 2023	34,640	49,559 (0%)	0%	73.5	2,547,311	Ordinary Shares, par value $0.01 per share
Tran B. Nguyen	Chief Strategy Officer and CFO	Sale of securities on an exchange or to another person at price $ 72.66 per share.	17 May 2023	14,001	84,199 (0%)	0%	72.7	1,017,325	Ordinary Shares, par value $0.01 per share
Tran B. Nguyen	Chief Strategy Officer and CFO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.85 per share.	17 May 2023	50,000	98,200 (0%)	0%	22.9	1,142,500	Ordinary Shares, par value $0.01 per share
Tran B. Nguyen	Chief Strategy Officer and CFO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 29.81 per share.	17 May 2023	45,000	48,200 (0%)	0%	29.8	1,341,450	Ordinary Shares, par value $0.01 per share
Tran B. Nguyen	Chief Strategy Officer and CFO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	17 May 2023	50,000	0	-		-	Stock Option (Right to Buy)
Tran B. Nguyen	Chief Strategy Officer and CFO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	17 May 2023	45,000	0	-		-	Stock Option (Right to Buy)
Tran B. Nguyen	Chief Strategy Officer and CFO	Sale of securities on an exchange or to another person at price $ 76.04 per share.	17 May 2023	100	3,200 (0%)	0%	76.0	7,604	Ordinary Shares, par value $0.01 per share
Helen S. Kim	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	17 May 2023	15,000	15,000	-		-	Stock Option (Right to Buy)
Richard Collier	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	17 May 2023	15,000	15,000	-		-	Stock Option (Right to Buy)
Dennis J Selkoe	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	17 May 2023	15,000	15,000	-		-	Stock Option (Right to Buy)
Lars G. Ekman	Director, Chair of the Board	Grant, award, or other acquisition of securities at price $ 0.00 per share.	17 May 2023	15,000	15,000	-		-	Stock Option (Right to Buy)
Shane M. Cooke	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	17 May 2023	15,000	15,000	-		-	Stock Option (Right to Buy)
Gene G. Kinney	President and CEO	Sale of securities on an exchange or to another person at price $ 74.49 per share.	17 May 2023	14,934	12,793 (0%)	0%	74.5	1,112,501	Ordinary Shares, par value $0.01 per share
Gene G. Kinney	President and CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 29.81 per share.	17 May 2023	45,000	57,793 (0%)	0%	29.8	1,341,450	Ordinary Shares, par value $0.01 per share
Gene G. Kinney	President and CEO	Sale of securities on an exchange or to another person at price $ 72.70 per share.	17 May 2023	10,202	47,591 (0%)	0%	72.7	741,721	Ordinary Shares, par value $0.01 per share
Gene G. Kinney	President and CEO	Sale of securities on an exchange or to another person at price $ 73.60 per share.	17 May 2023	19,864	27,727 (0%)	0%	73.6	1,462,070	Ordinary Shares, par value $0.01 per share
Gene G. Kinney	President and CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	17 May 2023	45,000	0	-		-	Stock Option (Right to Buy)
Anders O. Harfstrand	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	17 May 2023	15,000	15,000	-		-	Stock Option (Right to Buy)
Paula K. Cobb	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	17 May 2023	15,000	15,000	-		-	Stock Option (Right to Buy)
William H. Dunn	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	17 May 2023	30,000	30,000	-		-	Stock Option (Right to Buy)
Dennis J Selkoe	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 May 2023	9,000	6,000	-		-	Stock Option (Right to Buy)
Dennis J Selkoe	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 May 2023	6,000	0	-		-	Stock Option (Right to Buy)
Dennis J Selkoe	Director	Sale of securities on an exchange or to another person at price $ 57.00 per share.	03 May 2023	15,000	2,845 (0%)	0%	57	855,000	Ordinary Shares, par value $0.01 per share
Dennis J Selkoe	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 23.97 per share.	03 May 2023	9,000	17,845 (0%)	0%	24.0	215,730	Ordinary Shares, par value $0.01 per share
Dennis J Selkoe	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.23 per share.	03 May 2023	6,000	8,845 (0%)	0%	9.2	55,380	Ordinary Shares, par value $0.01 per share
Michael J. Malecek	Chief Legal Officer	Sale of securities on an exchange or to another person at price $ 53.40 per share.	26 Apr 2023	4,680	320 (0%)	0%	53.4	249,932	Ordinary Shares, par value $0.01 per share
Michael J. Malecek	Chief Legal Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.27 per share.	26 Apr 2023	5,000	5,000 (0%)	0%	10.3	51,350	Ordinary Shares, par value $0.01 per share
Michael J. Malecek	Chief Legal Officer	Sale of securities on an exchange or to another person at price $ 54.25 per share.	26 Apr 2023	320	0 (0%)	0%	54.3	17,361	Ordinary Shares, par value $0.01 per share
Michael J. Malecek	Chief Legal Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	26 Apr 2023	5,000	115,000	-		-	Stock Option (Right to Buy)
Karin L. Walker	Chief Accounting Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	19 Apr 2023	5,000	25,481	-		-	Stock Option (right to buy)
Karin L. Walker	Chief Accounting Officer	Sale of securities on an exchange or to another person at price $ 53.25 per share.	19 Apr 2023	2,083	0 (0%)	0%	53.2	110,917	Ordinary Shares, par value $0.01 per share
Karin L. Walker	Chief Accounting Officer	Sale of securities on an exchange or to another person at price $ 52.64 per share.	19 Apr 2023	2,917	2,083 (0%)	0%	52.6	153,563	Ordinary Shares, par value $0.01 per share
Karin L. Walker	Chief Accounting Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.04 per share.	19 Apr 2023	5,000	5,000 (0%)	0%	15.0	75,200	Ordinary Shares, par value $0.01 per share
Michael J. Malecek	Chief Legal Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	29 Mar 2023	5,000	120,000	-		-	Stock Option (Right to Buy)
Michael J. Malecek	Chief Legal Officer	Sale of securities on an exchange or to another person at price $ 49.28 per share.	29 Mar 2023	2,266	0 (0%)	0%	49.3	111,667	Ordinary Shares, par value $0.01 per share
Michael J. Malecek	Chief Legal Officer	Sale of securities on an exchange or to another person at price $ 48.81 per share.	29 Mar 2023	2,734	2,266 (0%)	0%	48.8	133,456	Ordinary Shares, par value $0.01 per share
Michael J. Malecek	Chief Legal Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.27 per share.	29 Mar 2023	5,000	5,000 (0%)	0%	10.3	51,350	Ordinary Shares, par value $0.01 per share
Karin L. Walker	Chief Accounting Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.04 per share.	20 Mar 2023	5,000	5,000 (0%)	0%	15.0	75,200	Ordinary Shares, par value $0.01 per share
Karin L. Walker	Chief Accounting Officer	Sale of securities on an exchange or to another person at price $ 47.51 per share.	20 Mar 2023	3,903	1,097 (0%)	0%	47.5	185,443	Ordinary Shares, par value $0.01 per share
Karin L. Walker	Chief Accounting Officer	Sale of securities on an exchange or to another person at price $ 48.46 per share.	20 Mar 2023	1,097	0 (0%)	0%	48.5	53,166	Ordinary Shares, par value $0.01 per share
Karin L. Walker	Chief Accounting Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	20 Mar 2023	5,000	30,481	-		-	Stock Option (right to buy)
Tran B. Nguyen	Chief Strategy Officer and CFO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.73 per share.	15 Mar 2023	10,000	13,200 (0%)	0%	6.7	67,300	Ordinary Shares, par value $0.01 per share
Tran B. Nguyen	Chief Strategy Officer and CFO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Mar 2023	10,000	0	-		-	Stock Option (Right to Buy)
Tran B. Nguyen	Chief Strategy Officer and CFO	Sale of securities on an exchange or to another person at price $ 48.68 per share.	15 Mar 2023	5,198	3,200 (0%)	0%	48.7	253,029	Ordinary Shares, par value $0.01 per share
Tran B. Nguyen	Chief Strategy Officer and CFO	Sale of securities on an exchange or to another person at price $ 48.16 per share.	15 Mar 2023	4,802	8,398 (0%)	0%	48.2	231,285	Ordinary Shares, par value $0.01 per share
Karin L. Walker	Chief Accounting Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Mar 2023	20,000	53,481	-		-	Stock Option (right to buy)
Karin L. Walker	Chief Accounting Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.04 per share.	15 Mar 2023	20,000	20,000 (0%)	0%	15.0	300,800	Ordinary Shares, par value $0.01 per share
Karin L. Walker	Chief Accounting Officer	Sale of securities on an exchange or to another person at price $ 48.14 per share.	15 Mar 2023	9,431	10,569 (0%)	0%	48.1	454,014	Ordinary Shares, par value $0.01 per share
Karin L. Walker	Chief Accounting Officer	Sale of securities on an exchange or to another person at price $ 48.66 per share.	15 Mar 2023	10,569	0 (0%)	0%	48.7	514,332	Ordinary Shares, par value $0.01 per share
Michael J. Malecek	Chief Legal Officer	Sale of securities on an exchange or to another person at price $ 48.13 per share.	15 Mar 2023	6,436	8,564 (0%)	0%	48.1	309,792	Ordinary Shares, par value $0.01 per share
Michael J. Malecek	Chief Legal Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Mar 2023	15,000	125,000	-		-	Stock Option (Right to Buy)
Michael J. Malecek	Chief Legal Officer	Sale of securities on an exchange or to another person at price $ 48.67 per share.	15 Mar 2023	8,564	0 (0%)	0%	48.7	416,800	Ordinary Shares, par value $0.01 per share
Michael J. Malecek	Chief Legal Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.27 per share.	15 Mar 2023	15,000	15,000 (0%)	0%	10.3	154,050	Ordinary Shares, par value $0.01 per share
Hideki Garren	Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Mar 2023	12,000	210,000	-		-	Stock Option (Right to Buy)
Hideki Garren	Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 24.90 per share.	15 Mar 2023	12,000	12,000 (0%)	0%	24.9	298,800	Ordinary Shares, par value $0.01 per share
Hideki Garren	Chief Medical Officer	Sale of securities on an exchange or to another person at price $ 48.66 per share.	15 Mar 2023	6,000	0 (0%)	0%	48.7	291,970	Ordinary Shares, par value $0.01 per share
Hideki Garren	Chief Medical Officer	Sale of securities on an exchange or to another person at price $ 48.16 per share.	15 Mar 2023	6,000	6,000 (0%)	0%	48.2	288,966	Ordinary Shares, par value $0.01 per share
Tran B. Nguyen	Chief Strategy Officer and CFO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	02 Mar 2023	48,000	48,000	-		-	Stock Option (Right to Buy)
Carol Karp	Chief Regulatory Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	02 Mar 2023	48,000	48,000	-		-	Stock Option (Right to Buy)
Karin L. Walker	Chief Accounting Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	02 Mar 2023	38,000	38,000	-		-	Stock Option (Right to Buy)
Gene G. Kinney	President and CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	02 Mar 2023	155,000	155,000	-		-	Stock Option (Right to Buy)
Wagner M. Zago	Chief Scientific Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	02 Mar 2023	48,000	48,000	-		-	Stock Option (Right to Buy)
Michael J. Malecek	Chief Legal Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	02 Mar 2023	48,000	48,000	-		-	Stock Option (Right to Buy)
Brandon S. Smith	Chief Operating Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	02 Mar 2023	48,000	48,000	-		-	Stock Option (Right to Buy)
Hideki Garren	Chief Medical Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	02 Mar 2023	48,000	48,000	-		-	Stock Option (Right to Buy)
Tran B. Nguyen	Chief Strategy Officer and CFO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Feb 2023	10,000	10,000	-		-	Stock Option (Right to Buy)
Tran B. Nguyen	Chief Strategy Officer and CFO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.73 per share.	15 Feb 2023	10,000	13,200 (0%)	0%	6.7	67,300	Ordinary Shares, par value $0.01 per share
Tran B. Nguyen	Chief Strategy Officer and CFO	Sale of securities on an exchange or to another person at price $ 53.30 per share.	15 Feb 2023	9,336	3,864 (0%)	0%	53.3	497,627	Ordinary Shares, par value $0.01 per share
Tran B. Nguyen	Chief Strategy Officer and CFO	Sale of securities on an exchange or to another person at price $ 53.87 per share.	15 Feb 2023	664	3,200 (0%)	0%	53.9	35,771	Ordinary Shares, par value $0.01 per share
Tran B. Nguyen	Chief Strategy Officer and CFO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	18 Jan 2023	10,000	20,000	-		-	Stock Option (Right to Buy)
Tran B. Nguyen	Chief Strategy Officer and CFO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.73 per share.	18 Jan 2023	10,000	13,200 (0%)	0%	6.7	67,300	Ordinary Shares, par value $0.01 per share
Tran B. Nguyen	Chief Strategy Officer and CFO	Sale of securities on an exchange or to another person at price $ 56.97 per share.	18 Jan 2023	638	3,200 (0%)	0%	57.0	36,347	Ordinary Shares, par value $0.01 per share
Tran B. Nguyen	Chief Strategy Officer and CFO	Sale of securities on an exchange or to another person at price $ 56.32 per share.	18 Jan 2023	2,085	3,838 (0%)	0%	56.3	117,436	Ordinary Shares, par value $0.01 per share
Tran B. Nguyen	Chief Strategy Officer and CFO	Sale of securities on an exchange or to another person at price $ 55.18 per share.	18 Jan 2023	7,277	5,923 (0%)	0%	55.2	401,523	Ordinary Shares, par value $0.01 per share
Shane M. Cooke	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	10 Jan 2023	5,000	0	-		-	Stock Option (Right to Buy)
Shane M. Cooke	Director	Sale of securities on an exchange or to another person at price $ 52.92 per share.	10 Jan 2023	5,000	0 (0%)	0%	52.9	264,608	Ordinary Shares, par value $0.01 per share
Shane M. Cooke	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.41 per share.	10 Jan 2023	5,000	5,000 (0%)	0%	6.4	32,050	Ordinary Shares, par value $0.01 per share
Richard Collier	Director	Sale of securities on an exchange or to another person at price $ 52.67 per share.	05 Jan 2023	5,000	1,219 (0%)	0%	52.7	263,350	Ordinary Shares, par value $0.01 per share
Richard Collier	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.41 per share.	05 Jan 2023	5,000	6,219 (0%)	0%	6.4	32,050	Ordinary Shares, par value $0.01 per share
Richard Collier	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	05 Jan 2023	5,000	0	-		-	Stock Option (Right to Buy)
Lars G. Ekman	Director, Chair of the Board	Sale of securities on an exchange or to another person at price $ 59.50 per share.	03 Jan 2023	10	312 (0%)	0%	59.5	595	Ordinary Shares, par value $0.01 per share
Lars G. Ekman	Director, Chair of the Board	Sale of securities on an exchange or to another person at price $ 58.67 per share.	03 Jan 2023	1,523	322 (0%)	0%	58.7	89,353	Ordinary Shares, par value $0.01 per share
Lars G. Ekman	Director, Chair of the Board	Sale of securities on an exchange or to another person at price $ 56.98 per share.	03 Jan 2023	1,303	1,845 (0%)	0%	57.0	74,244	Ordinary Shares, par value $0.01 per share
Lars G. Ekman	Director, Chair of the Board	Sale of securities on an exchange or to another person at price $ 56.33 per share.	03 Jan 2023	6,621	3,148 (0%)	0%	56.3	372,970	Ordinary Shares, par value $0.01 per share
Lars G. Ekman	Director, Chair of the Board	Sale of securities on an exchange or to another person at price $ 55.35 per share.	03 Jan 2023	2,897	9,769 (0%)	0%	55.3	160,341	Ordinary Shares, par value $0.01 per share
Lars G. Ekman	Director, Chair of the Board	Sale of securities on an exchange or to another person at price $ 54.15 per share.	03 Jan 2023	3,411	12,666 (0%)	0%	54.2	184,707	Ordinary Shares, par value $0.01 per share
Lars G. Ekman	Director, Chair of the Board	Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.41 per share.	03 Jan 2023	15,834	16,077 (0%)	0%	6.4	101,496	Ordinary Shares, par value $0.01 per share
Lars G. Ekman	Director, Chair of the Board	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Jan 2023	15,834	0	-		-	Stock Option (right to buy)
Lars G. Ekman	Director, Chair of the Board	Sale of securities on an exchange or to another person at price $ 60.84 per share.	03 Jan 2023	69	243 (0%)	0%	60.8	4,198	Ordinary Shares, par value $0.01 per share
Shane M. Cooke	Director	Sale of securities on an exchange or to another person at price $ 61.41 per share.	12 Dec 2022	3,887	0 (0%)	0%	61.4	238,706	Ordinary Shares, par value $0.01 per share
Shane M. Cooke	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	12 Dec 2022	5,000	5,000	-		-	Stock Option (Right to Buy)
Shane M. Cooke	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.41 per share.	12 Dec 2022	5,000	5,000 (0%)	0%	6.4	32,050	Ordinary Shares, par value $0.01 per share
Shane M. Cooke	Director	Sale of securities on an exchange or to another person at price $ 58.93 per share.	12 Dec 2022	332	4,668 (0%)	0%	58.9	19,565	Ordinary Shares, par value $0.01 per share
Shane M. Cooke	Director	Sale of securities on an exchange or to another person at price $ 60.08 per share.	12 Dec 2022	781	3,887 (0%)	0%	60.1	46,921	Ordinary Shares, par value $0.01 per share
Richard Collier	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.41 per share.	05 Dec 2022	5,000	6,219 (0%)	0%	6.4	32,050	Ordinary Shares, par value $0.01 per share
Richard Collier	Director	Sale of securities on an exchange or to another person at price $ 63.83 per share.	05 Dec 2022	647	2,168 (0%)	0%	63.8	41,296	Ordinary Shares, par value $0.01 per share
Richard Collier	Director	Sale of securities on an exchange or to another person at price $ 65.02 per share.	05 Dec 2022	949	1,219 (0%)	0%	65.0	61,701	Ordinary Shares, par value $0.01 per share
Richard Collier	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	05 Dec 2022	5,000	5,000	-		-	Stock Option (Right to Buy)
Richard Collier	Director	Sale of securities on an exchange or to another person at price $ 60.28 per share.	05 Dec 2022	1,915	4,304 (0%)	0%	60.3	115,429	Ordinary Shares, par value $0.01 per share
Richard Collier	Director	Sale of securities on an exchange or to another person at price $ 61.13 per share.	05 Dec 2022	913	3,391 (0%)	0%	61.1	55,809	Ordinary Shares, par value $0.01 per share
Richard Collier	Director	Sale of securities on an exchange or to another person at price $ 62.71 per share.	05 Dec 2022	576	2,815 (0%)	0%	62.7	36,121	Ordinary Shares, par value $0.01 per share
Lars G. Ekman	Director, Chair of the Board	Sale of securities on an exchange or to another person at price $ 61.28 per share.	01 Dec 2022	9,813	6,264 (0%)	0%	61.3	601,388	Ordinary Shares, par value $0.01 per share
Lars G. Ekman	Director, Chair of the Board	Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.41 per share.	01 Dec 2022	15,834	16,077 (0%)	0%	6.4	101,496	Ordinary Shares, par value $0.01 per share
Lars G. Ekman	Director, Chair of the Board	Sale of securities on an exchange or to another person at price $ 62.12 per share.	01 Dec 2022	6,021	243 (0%)	0%	62.1	374,018	Ordinary Shares, par value $0.01 per share
Lars G. Ekman	Director, Chair of the Board	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	01 Dec 2022	15,834	15,834	-		-	Stock Option (right to buy)
Hideki Garren	Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	01 Dec 2022	4,000	222,000	-		-	Stock Option (Right to Buy)
Hideki Garren	Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 24.90 per share.	01 Dec 2022	4,000	4,000 (0%)	0%	24.9	99,600	Ordinary Shares, par value $0.01 per share
Hideki Garren	Chief Medical Officer	Sale of securities on an exchange or to another person at price $ 62.51 per share.	01 Dec 2022	4,000	0 (0%)	0%	62.5	250,040	Ordinary Shares, par value $0.01 per share
Michael J. Malecek	Chief Legal Officer	Sale of securities on an exchange or to another person at price $ 59.92 per share.	30 Nov 2022	142	4,858 (0%)	0%	59.9	8,508	Ordinary Shares, par value $0.01 per share
Michael J. Malecek	Chief Legal Officer	Sale of securities on an exchange or to another person at price $ 60.96 per share.	30 Nov 2022	1,696	3,162 (0%)	0%	61.0	103,385	Ordinary Shares, par value $0.01 per share
Michael J. Malecek	Chief Legal Officer	Sale of securities on an exchange or to another person at price $ 62.06 per share.	30 Nov 2022	1,625	1,537 (0%)	0%	62.1	100,853	Ordinary Shares, par value $0.01 per share
Michael J. Malecek	Chief Legal Officer	Sale of securities on an exchange or to another person at price $ 62.85 per share.	30 Nov 2022	456	1,081 (0%)	0%	62.9	28,661	Ordinary Shares, par value $0.01 per share
Michael J. Malecek	Chief Legal Officer	Sale of securities on an exchange or to another person at price $ 64.13 per share.	30 Nov 2022	494	587 (0%)	0%	64.1	31,678	Ordinary Shares, par value $0.01 per share
Michael J. Malecek	Chief Legal Officer	Sale of securities on an exchange or to another person at price $ 64.96 per share.	30 Nov 2022	411	176 (0%)	0%	65.0	26,698	Ordinary Shares, par value $0.01 per share
Michael J. Malecek	Chief Legal Officer	Sale of securities on an exchange or to another person at price $ 65.86 per share.	30 Nov 2022	176	0 (0%)	0%	65.9	11,592	Ordinary Shares, par value $0.01 per share
Michael J. Malecek	Chief Legal Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	30 Nov 2022	5,000	140,000	-		-	Stock Option (Right to Buy)
Michael J. Malecek	Chief Legal Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.27 per share.	30 Nov 2022	5,000	5,000 (0%)	0%	10.3	51,350	Ordinary Shares, par value $0.01 per share
Shane M. Cooke	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.41 per share.	10 Nov 2022	5,000	5,000 (0%)	0%	6.4	32,050	Ordinary Shares, par value $0.01 per share
Shane M. Cooke	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	10 Nov 2022	5,000	10,000	-		-	Stock Option (Right to Buy)
Shane M. Cooke	Director	Sale of securities on an exchange or to another person at price $ 56.85 per share.	10 Nov 2022	875	0 (0%)	0%	56.9	49,745	Ordinary Shares, par value $0.01 per share
Shane M. Cooke	Director	Sale of securities on an exchange or to another person at price $ 56.14 per share.	10 Nov 2022	3,870	875 (0%)	0%	56.1	217,263	Ordinary Shares, par value $0.01 per share
Shane M. Cooke	Director	Sale of securities on an exchange or to another person at price $ 54.20 per share.	10 Nov 2022	255	4,745 (0%)	0%	54.2	13,820	Ordinary Shares, par value $0.01 per share
Richard Collier	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.41 per share.	07 Nov 2022	5,000	6,219 (0%)	0%	6.4	32,050	Ordinary Shares, par value $0.01 per share
Richard Collier	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	07 Nov 2022	5,000	10,000	-		-	Stock Option (Right to Buy)
Richard Collier	Director	Sale of securities on an exchange or to another person at price $ 56.89 per share.	07 Nov 2022	826	1,219 (0%)	0%	56.9	46,995	Ordinary Shares, par value $0.01 per share
Richard Collier	Director	Sale of securities on an exchange or to another person at price $ 55.71 per share.	07 Nov 2022	2,688	2,045 (0%)	0%	55.7	149,740	Ordinary Shares, par value $0.01 per share
Richard Collier	Director	Sale of securities on an exchange or to another person at price $ 54.74 per share.	07 Nov 2022	1,486	4,733 (0%)	0%	54.7	81,348	Ordinary Shares, par value $0.01 per share
Lars G. Ekman	Director, Chair of the Board	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	01 Nov 2022	15,833	31,668	-		-	Stock Option (right to buy)
Lars G. Ekman	Director, Chair of the Board	Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.41 per share.	01 Nov 2022	15,833	16,076 (0%)	0%	6.4	101,490	Ordinary Shares, par value $0.01 per share
Lars G. Ekman	Director, Chair of the Board	Sale of securities on an exchange or to another person at price $ 62.01 per share.	01 Nov 2022	9,143	6,933 (0%)	0%	62.0	566,953	Ordinary Shares, par value $0.01 per share
Lars G. Ekman	Director, Chair of the Board	Sale of securities on an exchange or to another person at price $ 62.91 per share.	01 Nov 2022	1,717	5,216 (0%)	0%	62.9	108,013	Ordinary Shares, par value $0.01 per share
Lars G. Ekman	Director, Chair of the Board	Sale of securities on an exchange or to another person at price $ 64.26 per share.	01 Nov 2022	3,312	1,904 (0%)	0%	64.3	212,824	Ordinary Shares, par value $0.01 per share
Lars G. Ekman	Director, Chair of the Board	Sale of securities on an exchange or to another person at price $ 64.94 per share.	01 Nov 2022	1,661	243 (0%)	0%	64.9	107,868	Ordinary Shares, par value $0.01 per share
Hideki Garren	Chief Medical Officer	Sale of securities on an exchange or to another person at price $ 62.41 per share.	01 Nov 2022	511	0 (0%)	0%	62.4	31,892	Ordinary Shares, par value $0.01 per share
Hideki Garren	Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	01 Nov 2022	4,000	226,000	-		-	Stock Option (Right to Buy)
Hideki Garren	Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 24.90 per share.	01 Nov 2022	4,000	4,000 (0%)	0%	24.9	99,600	Ordinary Shares, par value $0.01 per share
Hideki Garren	Chief Medical Officer	Sale of securities on an exchange or to another person at price $ 61.82 per share.	01 Nov 2022	3,489	511 (0%)	0%	61.8	215,683	Ordinary Shares, par value $0.01 per share
Karin L. Walker	Chief Accounting Officer	Sale of securities on an exchange or to another person at price $ 57.34 per share.	24 Oct 2022	7,144	4,949 (0%)	0%	57.3	409,603	Ordinary Shares, par value $0.01 per share
Karin L. Walker	Chief Accounting Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.04 per share.	24 Oct 2022	20,000	20,000 (0%)	0%	15.0	300,800	Ordinary Shares, par value $0.01 per share
Karin L. Walker	Chief Accounting Officer	Sale of securities on an exchange or to another person at price $ 56.39 per share.	24 Oct 2022	7,907	12,093 (0%)	0%	56.4	445,868	Ordinary Shares, par value $0.01 per share
Karin L. Walker	Chief Accounting Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	24 Oct 2022	20,000	65,481	-		-	Stock Option (right to buy)
Karin L. Walker	Chief Accounting Officer	Sale of securities on an exchange or to another person at price $ 58.98 per share.	24 Oct 2022	1,164	0 (0%)	0%	59.0	68,653	Ordinary Shares, par value $0.01 per share
Karin L. Walker	Chief Accounting Officer	Sale of securities on an exchange or to another person at price $ 58.25 per share.	24 Oct 2022	3,785	1,164 (0%)	0%	58.3	220,489	Ordinary Shares, par value $0.01 per share
Shane M. Cooke	Director	Sale of securities on an exchange or to another person at price $ 55.37 per share.	10 Oct 2022	2,324	2,676 (0%)	0%	55.4	128,681	Ordinary Shares, par value $0.01 per share
Shane M. Cooke	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	10 Oct 2022	5,000	15,000	-		-	Stock Option (Right to Buy)
Shane M. Cooke	Director	Sale of securities on an exchange or to another person at price $ 56.38 per share.	10 Oct 2022	2,676	0 (0%)	0%	56.4	150,869	Ordinary Shares, par value $0.01 per share
Shane M. Cooke	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.41 per share.	10 Oct 2022	5,000	5,000 (0%)	0%	6.4	32,050	Ordinary Shares, par value $0.01 per share
Lars G. Ekman	Director, Chair of the Board	Sale of securities on an exchange or to another person at price $ 62.96 per share.	03 Oct 2022	1,693	243 (0%)	0%	63.0	106,593	Ordinary Shares, par value $0.01 per share
Lars G. Ekman	Director, Chair of the Board	Sale of securities on an exchange or to another person at price $ 61.07 per share.	03 Oct 2022	4,277	8,291 (0%)	0%	61.1	261,208	Ordinary Shares, par value $0.01 per share
Lars G. Ekman	Director, Chair of the Board	Sale of securities on an exchange or to another person at price $ 60.32 per share.	03 Oct 2022	3,508	12,568 (0%)	0%	60.3	211,604	Ordinary Shares, par value $0.01 per share
Lars G. Ekman	Director, Chair of the Board	Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.41 per share.	03 Oct 2022	15,833	16,076 (0%)	0%	6.4	101,490	Ordinary Shares, par value $0.01 per share
Lars G. Ekman	Director, Chair of the Board	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Oct 2022	15,833	47,501	-		-	Stock Option (right to buy)
Lars G. Ekman	Director, Chair of the Board	Sale of securities on an exchange or to another person at price $ 62.10 per share.	03 Oct 2022	6,355	1,936 (0%)	0%	62.1	394,677	Ordinary Shares, par value $0.01 per share
Hideki Garren	Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Oct 2022	4,000	230,000	-		-	Stock Option (Right to Buy)
Hideki Garren	Chief Medical Officer	Sale of securities on an exchange or to another person at price $ 60.90 per share.	03 Oct 2022	4,000	0 (0%)	0%	60.9	243,600	Ordinary Shares, par value $0.01 per share
Hideki Garren	Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 24.90 per share.	03 Oct 2022	4,000	4,000 (0%)	0%	24.9	99,600	Ordinary Shares, par value $0.01 per share
Hideki Garren	Chief Medical Officer	Sale of securities on an exchange or to another person at price $ 30.52 per share.	01 Aug 2022	4,000	0 (0%)	0%	30.5	122,080	Ordinary Shares, par value $0.01 per share
Hideki Garren	Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 24.90 per share.	01 Aug 2022	4,000	4,000 (0%)	0%	24.9	99,600	Ordinary Shares, par value $0.01 per share
Hideki Garren	Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	01 Aug 2022	4,000	238,000	-		-	Stock Option (Right to Buy)
Shane M. Cooke	Director	Sale of securities on an exchange or to another person at price $ 35.76 per share.	11 Apr 2022	1,484	514 (0%)	0%	35.8	53,063	Ordinary Shares, par value $0.01 per share
Shane M. Cooke	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.41 per share.	11 Apr 2022	5,000	5,000 (0%)	0%	6.4	32,050	Ordinary Shares, par value $0.01 per share
Shane M. Cooke	Director	Sale of securities on an exchange or to another person at price $ 34.48 per share.	11 Apr 2022	3,002	1,998 (0%)	0%	34.5	103,506	Ordinary Shares, par value $0.01 per share
Shane M. Cooke	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	11 Apr 2022	5,000	45,000	-		-	Stock Option (Right to Buy)
Shane M. Cooke	Director	Sale of securities on an exchange or to another person at price $ 36.60 per share.	11 Apr 2022	514	0 (0%)	0%	36.6	18,812	Ordinary Shares, par value $0.01 per share
Richard Collier	Director	Sale of securities on an exchange or to another person at price $ 39.18 per share.	05 Apr 2022	2,631	3,588 (0%)	0%	39.2	103,073	Ordinary Shares, par value $0.01 per share
Richard Collier	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	05 Apr 2022	5,000	45,000	-		-	Stock Option (Right to Buy)
Richard Collier	Director	Sale of securities on an exchange or to another person at price $ 39.66 per share.	05 Apr 2022	2,369	1,219 (0%)	0%	39.7	93,954	Ordinary Shares, par value $0.01 per share
Richard Collier	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.41 per share.	05 Apr 2022	5,000	6,219 (0%)	0%	6.4	32,050	Ordinary Shares, par value $0.01 per share
Dennis J Selkoe	Director	Sale of securities on an exchange or to another person at price $ 46.81 per share.	03 Jan 2022	2,133	5,712 (0%)	0%	46.8	99,836	Ordinary Shares, par value $0.01 per share
Dennis J Selkoe	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Jan 2022	5,000	6,000	-		-	Stock Option (Right to Buy)
Dennis J Selkoe	Director	Sale of securities on an exchange or to another person at price $ 49.48 per share.	03 Jan 2022	492	2,845 (0%)	0%	49.5	24,343	Ordinary Shares, par value $0.01 per share
Dennis J Selkoe	Director	Sale of securities on an exchange or to another person at price $ 47.60 per share.	03 Jan 2022	2,375	3,337 (0%)	0%	47.6	113,054	Ordinary Shares, par value $0.01 per share
Dennis J Selkoe	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.23 per share.	03 Jan 2022	5,000	7,845 (0%)	0%	9.2	46,150	Ordinary Shares, par value $0.01 per share
Christopher S. Henney	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	14 Jul 2021	11,108	0	-		-	Stock Option (Right to Buy)
Christopher S. Henney	Director	Sale of securities on an exchange or to another person at price $ 56.13 per share.	14 Jul 2021	2,000	0 (0%)	0%	56.1	112,263	Ordinary Shares, par value $0.01 per share
Christopher S. Henney	Director	Sale of securities on an exchange or to another person at price $ 55.31 per share.	14 Jul 2021	9,108	2,000 (0%)	0%	55.3	503,757	Ordinary Shares, par value $0.01 per share
Christopher S. Henney	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 11.33 per share.	14 Jul 2021	11,108	11,108 (0%)	0%	11.3	125,854	Ordinary Shares, par value $0.01 per share
Christopher S. Henney	Director	Sale of securities on an exchange or to another person at price $ 59.45 per share.	12 Jul 2021	300	177 (0%)	0%	59.4	17,834	Ordinary Shares, par value $0.01 per share
Christopher S. Henney	Director	Sale of securities on an exchange or to another person at price $ 58.66 per share.	12 Jul 2021	800	477 (0%)	0%	58.7	46,924	Ordinary Shares, par value $0.01 per share
Christopher S. Henney	Director	Sale of securities on an exchange or to another person at price $ 57.85 per share.	12 Jul 2021	700	1,277 (0%)	0%	57.9	40,498	Ordinary Shares, par value $0.01 per share
Christopher S. Henney	Director	Sale of securities on an exchange or to another person at price $ 56.56 per share.	12 Jul 2021	2,100	1,977 (0%)	0%	56.6	118,767	Ordinary Shares, par value $0.01 per share
Christopher S. Henney	Director	Sale of securities on an exchange or to another person at price $ 55.26 per share.	12 Jul 2021	2,315	4,077 (0%)	0%	55.3	127,920	Ordinary Shares, par value $0.01 per share
Christopher S. Henney	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 11.33 per share.	12 Jul 2021	6,392	6,392 (0%)	0%	11.3	72,421	Ordinary Shares, par value $0.01 per share
Christopher S. Henney	Director	Sale of securities on an exchange or to another person at price $ 61.25 per share.	12 Jul 2021	177	0 (0%)	0%	61.2	10,841	Ordinary Shares, par value $0.01 per share
Christopher S. Henney	Director	Sale of securities on an exchange or to another person at price $ 59.24 per share.	12 Jul 2021	600	177 (0%)	0%	59.2	35,547	Ordinary Shares, par value $0.01 per share
Christopher S. Henney	Director	Sale of securities on an exchange or to another person at price $ 58.21 per share.	12 Jul 2021	500	777 (0%)	0%	58.2	29,106	Ordinary Shares, par value $0.01 per share
Christopher S. Henney	Director	Sale of securities on an exchange or to another person at price $ 56.88 per share.	12 Jul 2021	1,634	1,277 (0%)	0%	56.9	92,934	Ordinary Shares, par value $0.01 per share
Christopher S. Henney	Director	Sale of securities on an exchange or to another person at price $ 55.95 per share.	12 Jul 2021	2,475	2,911 (0%)	0%	55.9	138,476	Ordinary Shares, par value $0.01 per share
Christopher S. Henney	Director	Sale of securities on an exchange or to another person at price $ 54.55 per share.	12 Jul 2021	5,886	5,386 (0%)	0%	54.6	321,105	Ordinary Shares, par value $0.01 per share
Christopher S. Henney	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.23 per share.	12 Jul 2021	17,500	17,500 (0%)	0%	9.2	161,525	Ordinary Shares, par value $0.01 per share
Christopher S. Henney	Director	Sale of securities on an exchange or to another person at price $ 53.84 per share.	12 Jul 2021	6,228	11,272 (0%)	0%	53.8	335,334	Ordinary Shares, par value $0.01 per share
Christopher S. Henney	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	12 Jul 2021	6,392	11,108	-		-	Stock Option (Right to Buy)
Christopher S. Henney	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	12 Jul 2021	17,500	0	-		-	Stock Option (Right to Buy)
Christopher S. Henney	Director	Sale of securities on an exchange or to another person at price $ 61.25 per share.	12 Jul 2021	177	0 (0%)	0%	61.2	10,841	Ordinary Shares, par value $0.01 per share
Christopher S. Henney	Director	Sale of securities on an exchange or to another person at price $ 47.57 per share.	25 Jun 2021	10,264	1,736 (0%)	0%	47.6	488,223	Ordinary Shares, par value $0.01 per share
Christopher S. Henney	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	25 Jun 2021	12,000	0	-		-	Stock Option (Right to Buy)
Christopher S. Henney	Director	Sale of securities on an exchange or to another person at price $ 48.73 per share.	25 Jun 2021	1,736	0 (0%)	0%	48.7	84,597	Ordinary Shares, par value $0.01 per share
Christopher S. Henney	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.43 per share.	25 Jun 2021	12,000	12,000 (0%)	0%	16.4	197,160	Ordinary Shares, par value $0.01 per share
Wagner M. Zago	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 49.01 per share.	22 Jun 2021	5,203	0 (0%)	0%	49.0	254,986	Ordinary Shares, par value $0.01 per share
Wagner M. Zago	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	22 Jun 2021	81,250	68,750	-		-	Stock Option (Right to Buy)
Wagner M. Zago	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	22 Jun 2021	19,000	0	-		-	Stock Option (Right to Buy)
Wagner M. Zago	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	22 Jun 2021	15,000	0	-		-	Stock Option (Right to Buy)
Wagner M. Zago	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 47.81 per share.	22 Jun 2021	18,101	5,203 (0%)	0%	47.8	865,498	Ordinary Shares, par value $0.01 per share
Wagner M. Zago	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 46.27 per share.	22 Jun 2021	26,106	23,304 (0%)	0%	46.3	1,208,037	Ordinary Shares, par value $0.01 per share
Wagner M. Zago	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 45.42 per share.	22 Jun 2021	65,840	49,410 (0%)	0%	45.4	2,990,249	Ordinary Shares, par value $0.01 per share
Wagner M. Zago	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.04 per share.	22 Jun 2021	81,250	115,250 (0%)	0%	15.0	1,222,000	Ordinary Shares, par value $0.01 per share
Wagner M. Zago	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.81 per share.	22 Jun 2021	19,000	34,000 (0%)	0%	27.8	528,390	Ordinary Shares, par value $0.01 per share
Wagner M. Zago	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 20.17 per share.	22 Jun 2021	15,000	15,000 (0%)	0%	20.2	302,550	Ordinary Shares, par value $0.01 per share
Christopher S. Henney	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	19 May 2021	15,000	15,000	-		-	Stock Option (Right to Buy)
Richard Collier	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	19 May 2021	15,000	15,000	-		-	Stock Option (Right to Buy)
Dennis J Selkoe	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	19 May 2021	15,000	15,000	-		-	Stock Option (Right to Buy)
Lars G. Ekman	Director, Chairman of the Board	Grant, award, or other acquisition of securities at price $ 0.00 per share.	19 May 2021	15,000	15,000	-		-	Stock Option (Right to Buy)
Shane M. Cooke	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	19 May 2021	15,000	15,000	-		-	Stock Option (Right to Buy)
Anders O. Harfstrand	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	19 May 2021	15,000	15,000	-		-	Stock Option (Right to Buy)
Paula K. Cobb	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	19 May 2021	15,000	15,000	-		-	Stock Option (Right to Buy)
Sanjiv K. Patel	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	19 May 2021	30,000	30,000	-		-	Stock Option (Right to Buy)
Hideki Garren	Chief Medical Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	05 Apr 2021	250,000	250,000	-		-	Stock Option (Right to Buy)
Tran B. Nguyen	See Remarks	Grant, award, or other acquisition of securities at price $ 0.00 per share.	25 Feb 2021	84,000	84,000	-		-	Stock Option (Right to Buy)
Carol Karp	Chief Regulatory Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	25 Feb 2021	56,000	56,000	-		-	Stock Option (Right to Buy)
Karin L. Walker	Chief Accounting Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	25 Feb 2021	28,000	28,000	-		-	Employee Stock Option (Right to Buy)
Gene G. Kinney	President and CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	25 Feb 2021	250,000	250,000	-		-	Stock Option (Right to Buy)
Gene G. Kinney	President and CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	25 Feb 2021	50,000	50,000	-		-	Stock Option (Right to Buy)
Wagner M. Zago	Chief Scientific Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	25 Feb 2021	56,000	56,000	-		-	Stock Option (Right to Buy)
Radhika Tripuraneni	Chief Development Officer		25 Feb 2021	56,000	56,000	-		-	Stock Option (Right to Buy)
Michael J. Malecek	See Remarks	Grant, award, or other acquisition of securities at price $ 0.00 per share.	25 Feb 2021	56,000	56,000	-		-	Stock Option (Right to Buy)
Brandon S. Smith	Chief Business Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	25 Feb 2021	56,000	56,000	-		-	Stock Option (Right to Buy)
Christopher S. Henney	Director	Sale or transfer of securities back to the company at price $ 0.00 per share.	12 Feb 2021	15,000	0	-		-	Employee Stock Option (Right to Buy)
Christopher S. Henney	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Feb 2021	6,315	6,315	-		-	Employee Stock Option (Right to Buy)
Christopher S. Henney	Director	Sale or transfer of securities back to the company at price $ 0.00 per share.	12 Feb 2021	12,000	0	-		-	Employee Stock Option (Right to Buy)
Christopher S. Henney	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Feb 2021	8,426	8,426	-		-	Employee Stock Option (Right to Buy)
Christopher S. Henney	Director	Sale or transfer of securities back to the company at price $ 0.00 per share.	12 Feb 2021	15,000	0	-		-	Employee Stock Option (Right to Buy)
Christopher S. Henney	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Feb 2021	9,803	9,803	-		-	Employee Stock Option (Right to Buy)
Tran B. Nguyen	See Remarks	Sale or transfer of securities back to the company at price $ 0.00 per share.	12 Feb 2021	75,000	0	-		-	Employee Stock Option (Right to Buy)
Tran B. Nguyen	See Remarks	Sale or transfer of securities back to the company at price $ 0.00 per share.	12 Feb 2021	55,000	0	-		-	Employee Stock Option (Right to Buy)
Tran B. Nguyen	See Remarks	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Feb 2021	50,000	50,000	-		-	Employee Stock Option (Right to Buy)
Tran B. Nguyen	See Remarks	Sale or transfer of securities back to the company at price $ 0.00 per share.	12 Feb 2021	65,000	0	-		-	Employee Stock Option (Right to Buy)
Tran B. Nguyen	See Remarks	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Feb 2021	40,625	40,625	-		-	Employee Stock Option (Right to Buy)
Tran B. Nguyen	See Remarks	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Feb 2021	39,062	39,062	-		-	Employee Stock Option (Right to Buy)
Tran B. Nguyen	See Remarks	Sale or transfer of securities back to the company at price $ 0.00 per share.	12 Feb 2021	80,000	0	-		-	Employee Stock Option (Right to Buy)
Tran B. Nguyen	See Remarks	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Feb 2021	60,150	60,150	-		-	Employee Stock Option (Right to Buy)
Richard Collier	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Feb 2021	8,426	8,426	-		-	Employee Stock Option (Right to Buy)
Richard Collier	Director	Sale or transfer of securities back to the company at price $ 0.00 per share.	12 Feb 2021	12,000	0	-		-	Employee Stock Option (Right to Buy)
Richard Collier	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Feb 2021	6,315	6,315	-		-	Employee Stock Option (Right to Buy)
Richard Collier	Director	Sale or transfer of securities back to the company at price $ 0.00 per share.	12 Feb 2021	15,000	0	-		-	Employee Stock Option (Right to Buy)
Richard Collier	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Feb 2021	9,803	9,803	-		-	Employee Stock Option (Right to Buy)
Richard Collier	Director	Sale or transfer of securities back to the company at price $ 0.00 per share.	12 Feb 2021	15,000	0	-		-	Employee Stock Option (Right to Buy)
Dennis J Selkoe	Director	Sale or transfer of securities back to the company at price $ 0.00 per share.	12 Feb 2021	15,000	0	-		-	Employee Stock Option (Right to Buy)
Dennis J Selkoe	Director	Sale or transfer of securities back to the company at price $ 0.00 per share.	12 Feb 2021	12,000	0	-		-	Employee Stock Option (Right to Buy)
Dennis J Selkoe	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Feb 2021	6,315	6,315	-		-	Employee Stock Option (Right to Buy)
Dennis J Selkoe	Director	Sale or transfer of securities back to the company at price $ 0.00 per share.	12 Feb 2021	15,000	0	-		-	Employee Stock Option (Right to Buy)
Dennis J Selkoe	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Feb 2021	9,803	9,803	-		-	Employee Stock Option (Right to Buy)
Dennis J Selkoe	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Feb 2021	8,426	8,426	-		-	Employee Stock Option (Right to Buy)
Lars G. Ekman	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Feb 2021	8,426	8,426	-		-	Employee Stock Option (Right to Buy)
Lars G. Ekman	Director	Sale or transfer of securities back to the company at price $ 0.00 per share.	12 Feb 2021	15,000	0	-		-	Employee Stock Option (Right to Buy)
Lars G. Ekman	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Feb 2021	9,803	9,803	-		-	Employee Stock Option (Right to Buy)
Lars G. Ekman	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Feb 2021	6,315	6,315	-		-	Employee Stock Option (Right to Buy)
Lars G. Ekman	Director	Sale or transfer of securities back to the company at price $ 0.00 per share.	12 Feb 2021	12,000	0	-		-	Employee Stock Option (Right to Buy)
Lars G. Ekman	Director	Sale or transfer of securities back to the company at price $ 0.00 per share.	12 Feb 2021	15,000	0	-		-	Employee Stock Option (Right to Buy)
Shane M. Cooke	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Feb 2021	9,803	9,803	-		-	Employee Stock Option (Right to Buy)
Shane M. Cooke	Director	Sale or transfer of securities back to the company at price $ 0.00 per share.	12 Feb 2021	15,000	0	-		-	Employee Stock Option (Right to Buy)
Shane M. Cooke	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Feb 2021	6,315	6,315	-		-	Employee Stock Option (Right to Buy)
Shane M. Cooke	Director	Sale or transfer of securities back to the company at price $ 0.00 per share.	12 Feb 2021	12,000	0	-		-	Employee Stock Option (Right to Buy)
Shane M. Cooke	Director	Sale or transfer of securities back to the company at price $ 0.00 per share.	12 Feb 2021	15,000	0	-		-	Employee Stock Option (Right to Buy)
Shane M. Cooke	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Feb 2021	8,426	8,426	-		-	Employee Stock Option (Right to Buy)
Carol Karp	Chief Regulatory Officer	Sale or transfer of securities back to the company at price $ 0.00 per share.	12 Feb 2021	60,000	0	-		-	Employee Stock Option (Right to Buy)
Carol Karp	Chief Regulatory Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Feb 2021	45,112	45,112	-		-	Employee Stock Option (Right to Buy)
Carol Karp	Chief Regulatory Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Feb 2021	51,282	51,282	-		-	Employee Stock Option (Right to Buy)
Carol Karp	Chief Regulatory Officer	Sale or transfer of securities back to the company at price $ 0.00 per share.	12 Feb 2021	100,000	0	-		-	Employee Stock Option (Right to Buy)
Karin L. Walker	Chief Accounting Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Feb 2021	15,625	15,625	-		-	Employee Stock Option (Right to Buy)
Karin L. Walker	Chief Accounting Officer	Sale or transfer of securities back to the company at price $ 0.00 per share.	12 Feb 2021	30,000	0	-		-	Employee Stock Option (Right to Buy)
Karin L. Walker	Chief Accounting Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Feb 2021	15,625	15,625	-		-	Employee Stock Option (Right to Buy)
Karin L. Walker	Chief Accounting Officer	Sale or transfer of securities back to the company at price $ 0.00 per share.	12 Feb 2021	25,000	0	-		-	Employee Stock Option (Right to Buy)
Karin L. Walker	Chief Accounting Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Feb 2021	15,909	15,909	-		-	Employee Stock Option (Right to Buy)
Karin L. Walker	Chief Accounting Officer	Sale or transfer of securities back to the company at price $ 0.00 per share.	12 Feb 2021	17,500	0	-		-	Employee Stock Option (Right to Buy)
Karin L. Walker	Chief Accounting Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Feb 2021	18,796	18,796	-		-	Employee Stock Option (Right to Buy)
Karin L. Walker	Chief Accounting Officer	Sale or transfer of securities back to the company at price $ 0.00 per share.	12 Feb 2021	25,000	0	-		-	Employee Stock Option (Right to Buy)
Gene G. Kinney	Director, President and CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Feb 2021	25,125	25,125	-		-	Employee Stock Option (Right to Buy)
Gene G. Kinney	Director, President and CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Feb 2021	140,601	140,601	-		-	Employee Stock Option (Right to Buy)
Gene G. Kinney	Director, President and CEO	Sale or transfer of securities back to the company at price $ 0.00 per share.	12 Feb 2021	187,000	0	-		-	Employee Stock Option (Right to Buy)
Gene G. Kinney	Director, President and CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Feb 2021	62,500	62,500	-		-	Employee Stock Option (Right to Buy)
Gene G. Kinney	Director, President and CEO	Sale or transfer of securities back to the company at price $ 0.00 per share.	12 Feb 2021	120,000	0	-		-	Employee Stock Option (Right to Buy)
Gene G. Kinney	Director, President and CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Feb 2021	16,759	16,759	-		-	Employee Stock Option (Right to Buy)
Gene G. Kinney	Director, President and CEO	Sale or transfer of securities back to the company at price $ 0.00 per share.	12 Feb 2021	30,000	0	-		-	Employee Stock Option (Right to Buy)
Gene G. Kinney	Director, President and CEO	Sale or transfer of securities back to the company at price $ 0.00 per share.	12 Feb 2021	50,000	0	-		-	Employee Stock Option (Right to Buy)
Gene G. Kinney	Director, President and CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Feb 2021	40,625	40,625	-		-	Employee Stock Option (Right to Buy)
Gene G. Kinney	Director, President and CEO	Sale or transfer of securities back to the company at price $ 0.00 per share.	12 Feb 2021	65,000	0	-		-	Employee Stock Option (Right to Buy)
Gene G. Kinney	Director, President and CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Feb 2021	59,090	59,090	-		-	Employee Stock Option (Right to Buy)
Gene G. Kinney	Director, President and CEO	Sale or transfer of securities back to the company at price $ 0.00 per share.	12 Feb 2021	65,000	0	-		-	Employee Stock Option (Right to Buy)
Anders O. Harfstrand	Director	Sale or transfer of securities back to the company at price $ 0.00 per share.	12 Feb 2021	30,000	0	-		-	Employee Stock Option (Right to Buy)
Anders O. Harfstrand	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Feb 2021	8,426	8,426	-		-	Employee Stock Option (Right to Buy)
Anders O. Harfstrand	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Feb 2021	6,315	6,315	-		-	Employee Stock Option (Right to Buy)
Anders O. Harfstrand	Director	Sale or transfer of securities back to the company at price $ 0.00 per share.	12 Feb 2021	15,000	0	-		-	Employee Stock Option (Right to Buy)
Anders O. Harfstrand	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Feb 2021	15,873	15,873	-		-	Employee Stock Option (Right to Buy)
Anders O. Harfstrand	Director	Sale or transfer of securities back to the company at price $ 0.00 per share.	12 Feb 2021	12,000	0	-		-	Employee Stock Option (Right to Buy)
Wagner M. Zago	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 20.00 per share.	12 Feb 2021	18,750	0 (0%)	0%	20.0	375,008	Ordinary Shares, par value $0.01 per share
Wagner M. Zago	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.53 per share.	12 Feb 2021	18,750	18,750 (0%)	0%	13.5	253,688	Ordinary Shares, par value $0.01 per share
Wagner M. Zago	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 17.07 per share.	12 Feb 2021	7,560	0 (0%)	0%	17.1	129,049	Ordinary Shares, par value $0.01 per share
Wagner M. Zago	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.41 per share.	12 Feb 2021	7,540	7,540 (0%)	0%	6.4	48,331	Ordinary Shares, par value $0.01 per share
Wagner M. Zago	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 25.50 per share.	12 Feb 2021	7,540	0 (0%)	0%	25.5	192,270	Ordinary Shares, par value $0.01 per share
Wagner M. Zago	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	12 Feb 2021	7,540	0	-		-	Stock Option (Right to Buy)
Wagner M. Zago	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	12 Feb 2021	18,750	31,250	-		-	Stock Option (Right to Buy)
Wagner M. Zago	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	12 Feb 2021	7,560	7,540	-		-	Stock Option (Right to Buy)
Wagner M. Zago	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.41 per share.	12 Feb 2021	7,560	7,560 (0%)	0%	6.4	48,460	Ordinary Shares, par value $0.01 per share
Radhika Tripuraneni	Chief Development Officer		12 Feb 2021	37,037	37,037	-		-	Employee Stock Option (Right to Buy)
Radhika Tripuraneni	Chief Development Officer		12 Feb 2021	50,000	0	-		-	Employee Stock Option (Right to Buy)
Gene G. Kinney	Director, President and CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	17 Aug 2020	10,000	99,074	-		-	Stock Option (Right to Buy)
Gene G. Kinney	Director, President and CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.41 per share.	17 Aug 2020	10,000	12,793 (0%)	0%	6.4	64,100	Ordinary Shares, par value $0.01 per share
Christopher S. Henney	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	20 May 2020	17,500	17,500	-		-	Stock Option (Right to Buy)
T.	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	20 May 2020	17,500	17,500	-		-	Stock Option (Right to Buy)
J.	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	20 May 2020	17,500	17,500	-		-	Stock Option (Right to Buy)
Lars G. Ekman	Other, Chairman of the Board	Grant, award, or other acquisition of securities at price $ 0.00 per share.	20 May 2020	17,500	17,500	-		-	Stock Option (Right to Buy)
Shane M. Cooke	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	20 May 2020	17,500	17,500	-		-	Stock Option (Right to Buy)
K. Anders	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	20 May 2020	17,500	17,500	-		-	Stock Option (Right to Buy)
Paula K. Cobb	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	20 May 2020	17,500	17,500	-		-	Stock Option (Right to Buy)
Tran B. Nguyen	Chief Strategy Officer and CFO	Other type of transaction at price $ 0.00 per share.	08 Apr 2020	995	2,205 (0%)	0%		0	Ordinary Shares, par value $0.01 per share
Brandon S. Smith	Chief Business Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	02 Mar 2020	240,000	240,000	-		-	Stock Option (Right to Buy)
Tran B. Nguyen	See Remarks	Grant, award, or other acquisition of securities at price $ 0.00 per share.	25 Feb 2020	105,000	105,000	-		-	Stock Option (Right to Buy)
D.	Chief Regulatory Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	25 Feb 2020	70,000	70,000	-		-	Stock Option (Right to Buy)
Karin L. Walker	See Remarks	Grant, award, or other acquisition of securities at price $ 0.00 per share.	25 Feb 2020	40,000	40,000	-		-	Stock Option (Right to Buy)
Gene G. Kinney	President and CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	25 Feb 2020	200,000	200,000	-		-	Stock Option (Right to Buy)
Wagner M. Zago	Chief Scientific Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	25 Feb 2020	70,000	70,000	-		-	Stock Option (Right to Buy)
Radhika Tripuraneni	Chief Development Officer		25 Feb 2020	70,000	70,000	-		-	Stock Option (Right to Buy)
Michael J. Malecek	See Remarks	Grant, award, or other acquisition of securities at price $ 0.00 per share.	25 Feb 2020	70,000	70,000	-		-	Stock Option (Right to Buy)
Paula K. Cobb	None	Grant, award, or other acquisition of securities at price $ 0.00 per share.	02 Jul 2019	35,000	35,000	-		-	Stock Option (Right to Buy)
Michael J. Malecek	See Remarks	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Jul 2019	250,000	250,000	-		-	Stock Option (Right to Buy)
Christopher S. Henney	None	Grant, award, or other acquisition of securities at price $ 0.00 per share.	22 May 2019	17,500	17,500	-		-	Stock Option (Right to Buy)
Richard Collier	None	Grant, award, or other acquisition of securities at price $ 0.00 per share.	22 May 2019	17,500	17,500	-		-	Stock Option (Right to Buy)
Dennis J Selkoe	None	Grant, award, or other acquisition of securities at price $ 0.00 per share.	22 May 2019	17,500	17,500	-		-	Stock Option (Right to Buy)
Lars G. Ekman	Other	Grant, award, or other acquisition of securities at price $ 0.00 per share.	22 May 2019	17,500	17,500	-		-	Stock Option (Right to Buy)
Shane M. Cooke	None	Grant, award, or other acquisition of securities at price $ 0.00 per share.	22 May 2019	17,500	17,500	-		-	Stock Option (Right to Buy)
Anders O. Harfstrand	None	Grant, award, or other acquisition of securities at price $ 0.00 per share.	22 May 2019	17,500	17,500	-		-	Stock Option (Right to Buy)
Tran B. Nguyen	See Remarks	Grant, award, or other acquisition of securities at price $ 0.00 per share.	27 Feb 2019	95,000	95,000	-		-	Stock Option (right to buy)
Carol Karp	Chief Regulatory Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	27 Feb 2019	50,000	50,000	-		-	Stock Option (right to buy)
Karin L. Walker	See Remarks	Grant, award, or other acquisition of securities at price $ 0.00 per share.	27 Feb 2019	35,000	35,000	-		-	Stock Option (right to buy)
Gene G. Kinney	Director, President and CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	27 Feb 2019	245,000	245,000	-		-	Stock Option (right to buy)
Wagner M. Zago	Chief Scientific Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	27 Feb 2019	50,000	50,000	-		-	Stock Option (right to buy)
Radhika Tripuraneni	Chief Development Officer		27 Feb 2019	50,000	50,000	-		-	Stock Option (right to buy)
Radhika Tripuraneni	Chief Development Officer		11 Dec 2018	35,000	35,000	-		-	Stock Option (right to buy)
Tran B. Nguyen	COO and CFO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Jun 2018	250,000	250,000	-		-	Stock Option (right to buy)
A. W. Homan	Chief Legal Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Jun 2018	150,000	150,000	-		-	Stock Option(right to buy)
Carol Karp	Chief Regulatory Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Jun 2018	150,000	150,000	-		-	Stock Option (right to buy)
Karin L. Walker	See Remarks	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Jun 2018	110,000	110,000	-		-	Stock Option (right to buy)
Gene G. Kinney	Director, President and CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Jun 2018	620,000	620,000	-		-	Stock Option (right to buy)
Wagner M. Zago	Chief Scientific Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Jun 2018	150,000	150,000	-		-	Stock Option (right to buy)
Christopher S. Henney	None	Grant, award, or other acquisition of securities at price $ 0.00 per share.	16 May 2018	12,000	12,000	-		-	Stock Option (right to buy)
Richard Collier	None	Grant, award, or other acquisition of securities at price $ 0.00 per share.	16 May 2018	12,000	12,000	-		-	Stock Option (right to buy)
Dennis J Selkoe	None	Grant, award, or other acquisition of securities at price $ 0.00 per share.	16 May 2018	12,000	12,000	-		-	Stock Option(right to buy)
Lars G. Ekman	Other	Grant, award, or other acquisition of securities at price $ 0.00 per share.	16 May 2018	12,000	12,000	-		-	Stock Option(right to buy)
Shane M. Cooke	None	Grant, award, or other acquisition of securities at price $ 0.00 per share.	16 May 2018	12,000	12,000	-		-	Stock Option (right to buy)
Anders O. Harfstrand	None	Grant, award, or other acquisition of securities at price $ 0.00 per share.	16 May 2018	12,000	12,000	-		-	Stock Option (right to buy)
Tran B. Nguyen	Chief Financial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Feb 2018	80,000	80,000	-		-	Stock Option (right to buy)
A. W. Homan	Chief Legal Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Feb 2018	60,000	60,000	-		-	Stock Option (right to buy)
Carol Karp	Chief Regulatory Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Feb 2018	60,000	60,000	-		-	Stock Option (right to buy)
Karin L. Walker	See Remarks	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Feb 2018	25,000	25,000	-		-	Stock Option (right to buy)
Gene G. Kinney	Director, President and CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Feb 2018	187,000	187,000	-		-	Stock Option (right to buy)
Tara Nickerson	Chief Business Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Feb 2018	45,000	45,000	-		-	Stock Option (right to buy)
Wagner M. Zago	Chief Scientific Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Feb 2018	60,000	60,000	-		-	Stock Option (right to buy)
Dennis J Selkoe	None	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	02 Oct 2017	3,500	3,500	-		-	Stock Option (right to buy)
Dennis J Selkoe	None	Sale of securities on an exchange or to another person at price $ 64.13 per share.	02 Oct 2017	3,299	3,046 (0%)	0%	64.1	211,564	Ordinary Shares, par value $0.01 per share
Dennis J Selkoe	None	Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.42 per share.	02 Oct 2017	3,500	6,345 (0%)	0%	16.4	57,470	Ordinary Shares, par value $0.01 per share
Dennis J Selkoe	None	Sale of securities on an exchange or to another person at price $ 64.77 per share.	02 Oct 2017	201	2,845 (0%)	0%	64.8	13,019	Ordinary Shares, par value $0.01 per share
Christopher S. Henney	None	Sale of securities on an exchange or to another person at price $ 70.00 per share.	28 Sep 2017	900	0 (0%)	0%	70	63,000	Ordinary Shares, par value $0.01 per share
Christopher S. Henney	None	Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.65 per share.	28 Sep 2017	900	900 (0%)	0%	6.7	5,985	Ordinary Shares, par value $0.01 per share
Christopher S. Henney	None	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	28 Sep 2017	900	14,100	-		-	Stock Option (right to buy)
Karin L. Walker	See Remarks	Sale of securities on an exchange or to another person at price $ 70.00 per share.	28 Sep 2017	1,500	0 (0%)	0%	70	105,000	Ordinary Shares, par value $0.01 per share
Karin L. Walker	See Remarks	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	28 Sep 2017	1,500	17,500	-		-	Stock Option(right to buy)
Karin L. Walker	See Remarks	Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.81 per share.	28 Sep 2017	1,500	1,500 (0%)	0%	27.8	41,715	Ordinary Shares, par value $0.01 per share
Gene G. Kinney	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 70.00 per share.	28 Sep 2017	2,800	2,793 (0%)	0%	70	196,000	Ordinary Shares, par value $0.01 per share
Gene G. Kinney	Director, President and CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.41 per share.	28 Sep 2017	2,800	5,593 (0%)	0%	6.4	17,948	Ordinary Shares, par value $0.01 per share
Gene G. Kinney	Director, President and CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	28 Sep 2017	2,800	109,074	-		-	Stock Option (right to buy)
Wagner M. Zago	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.41 per share.	28 Sep 2017	900	900 (0%)	0%	6.4	5,769	Ordinary Shares, par value $0.01 per share
Wagner M. Zago	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 70.00 per share.	28 Sep 2017	900	0 (0%)	0%	70	63,000	Ordinary Shares, par value $0.01 per share
Wagner M. Zago	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	28 Sep 2017	900	15,100	-		-	Stock Option (right to buy)
Tara Nickerson	Chief Business Officer	Sale of securities on an exchange or to another person at price $ 69.05 per share.	27 Sep 2017	4,724	2,000 (0%)	0%	69.0	326,189	Ordinary Shares, par value $0.01 per share
Tara Nickerson	Chief Business Officer	Sale of securities on an exchange or to another person at price $ 69.20 per share.	27 Sep 2017	12,776	2,000 (0%)	0%	69.2	884,056	Ordinary Shares, par value $0.01 per share
Tara Nickerson	Chief Business Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	27 Sep 2017	4,724	31,276	-		-	Stock Option (right to buy)
Tara Nickerson	Chief Business Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	27 Sep 2017	12,776	18,500	-		-	Stock Option (right to buy)
Tara Nickerson	Chief Business Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.73 per share.	27 Sep 2017	4,724	6,724 (0%)	0%	6.7	31,793	Ordinary Shares, par value $0.01 per share

*All Values are in $ Million

Client Category: Promoter/ KMP/ Director / Immediate Relatives / Employee / etc
Security Type: Share/ Warrants / Convertible Debentures

Data as reported to USA Exchanges

View All The Insider Trades disclosures

49.39% Fall from 52W High

Insider Trading disclosures for Prothena Corporation plc

The latest disclosure was made by Tran B. Nguyen in Prothena Corporation plc where a trade of 107,500 Stock Option (Right to Buy) done was reported to US exchanges on March 5, 2025.

Screeners based on Insider Trading and SAST parameters